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The purine analogs 2 deoxycorformycin and 2-deoxyadenosine induce responses in >95% of patients, most of them complete and durable. HCL-V is not responsive to the above treatments with only half achieving transient celebrity photos partial responses to the purine analogs with splenectomy being the best palliative therapeutic measure. Evolution HCL and HCL-V celebrity photos are characterised by a chronic clinical course with the symptoms deriving from cytopenias, and abdominal distension due to splenomegaly. Few patients undergo transformation. Prognosis HCL has a good prognosis .In a large series 80% of patients survived at 12 years. HCL -V has a poorer celebrity photos prognosis and in the only largest series reported the median survival is 9 years. CytogeneticsCytogenetics Morphological Several reports describe nonclonal or oligoclonal abnormalities in HCL and in some with clonal abnormalities translocations involving the 14q32.3 the site of the IGH locus, rearrangements of 14q22-24 and abnormalities of chromosomes 11 and 12 have been described.
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