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Italian Cooperative Group for Hairy Cell Leukemia. Leuk Lymphoma 13 (3-4): 307-16, 1994. Kurzrock R, brian p. cleary Strom SS, Estey E, et al.: Second cancer risk in hairy cell leukemia: analysis of 350 patients. J Clin brian p. cleary Oncol 15 (5): 1803-10, 1997. Treatment Option Overview The initial therapies of choice are either cladribine (2-chlorodeoxyadenosine, 2-CdA) or pentostatin. [1] These drugs have comparable response rates but have not been compared in phase III trials. Cladribine is administered as a one-time continuous infusion or series of subcutaneous injections and is associated brian p. cleary with a high rate of febrile neutropenia. [2] [3] [4] [5] Rarely, more than one course of treatment is required to induce a desirable response.
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