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[16] Remission can be prolonged with a low-dose maintenance regimen. [17] A randomized comparison of pentostatin and interferon alfa demonstrated significantly higher and more durable responses to pentostatin. [12] Splenectomy will papillae partially or completely normalize the peripheral blood in the vast majority of patients with hairy cell leukemia. [18] Usually little or no change occurs in the bone marrow after splenectomy, and virtually all patients have progressive disease within 12 to 18 months. papillae Therefore, since a papillae number of more effective alternatives are available, splenectomy is playing a decreasing role in the treatment of this disease. References: Saven A, Piro L: Newer purine analogues for the treatment of hairy-cell leukemia.
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