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| madonna, glbt, gif, what is hairy cunts, british english, dairy, quotations, expressionism, games, 40k, | [12][Level of evidence: 3iiiDiii] Allogeneic bone marrow transplantation may be considered for selected patients in rare instances. The patients should be in good health and have an HLA-identical toilet paper sibling. The high mortality of this procedure justifies its use only in refractory cases. [13] Aggressive, high-dose chemotherapy has been beneficial in some cases, but the associated morbidity and mortality are high. It should not be considered unless other, more frequently effective therapies have toilet paper been exhausted. References: Blick M, Lepe-Zuniga JL, Doig R, et al.: Durable complete remissions after 2'-deoxycoformycin toilet paper treatment in patients with hairy cell leukemia resistant to interferon alpha. Am J Hematol 33 (3): 205-9, 1990. Piro LD, Carrera CJ, Carson DA, et al.: Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine. |
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| The PDQ editorial boards use a formal ranking system to help the reader glbt judge the strength of evidence linked to the reported results of a therapeutic strategy. (Refer to the PDQ summary on Levels of Evidence for more information.) Cladribine (2-chlorodeoxyadenosine, 2-CdA) and pentostatin are both highly efficacious in the treatment of glbt patients with disease refractory to interferon alfa. [1] [2] [3] [4] Rituximab can induce durable complete remissions with minimal toxic effects in the majority of patients with relapsing or refractory disease after purine analog therapy. glbt [5] [6] [7][Level of evidence: 3iiiDiii] The lack of subsequent immunosuppression with rituximab has made this treatment the first choice among relapsing patients in the absence of a clinical trial. [7] Patients who relapse after cladribine or pentostatin often respond to retreatment with the same or another purine analog. [8] [9] [10] [11] An anti-CD22 recombinant immunotoxin under clinical evaluation can induce complete remissions in patients resistant to retreatment with purine analogs. |
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